False Positive Rubella Test In Pregnancy
نویسنده
چکیده
A 28 years female pregnant; 15 week +3 days gestational age, G0, P1, A0; presented for routine antenatal care visit in primary health care center. She had done the investigation in privet hospital showing rubella +ve IgM, CMV +ve IgG. Taking full history, the patient had simple flu like illness several weeks ago with no treatment is needed, no recent contact with a case of rubella nor recent vaccination. By examination, the patient is clinically normal. Ultrasound is done, no congenital anomaly, no signs of fetal infection, normal fetal wellbeing. I advise the patient to repeat the TORCH panel in 2 weeks later. The result by now; is showing rubella -ve IgM, CMV +ve IgG. Rubella false positive result can occur that require special attention to avoid termination of healthy pregnancy.
منابع مشابه
Nonspecific reactions in the hemagglutination inhibition test for detection of rubella antibodies.
Approximately 7% of the sera tested to determine the presence of rubella-specific antibodies by the hemagglutination inhibition test demonstrated abnormal patterns of reactivity, rendering the test unreadable. Another 3% of sera were shown to have false-positive titers as high as 1:128. When these abnormally reacting and false-positive sera were heated at 56 degrees C for 30 min after chemical ...
متن کاملRubella hemagglutination-inhibition test: false-positive reactions in sera contaminated with bacteria.
We have shown that bacterial contamination of sera can have a marked influence on the results of the rubella hemagglutination-inhibition (HI) test. In addition to increasing the levels of nonspecific agglutinins, a number of common bacterial species tested had a significant effect on the HI titers. When sera free from rubella-specific antibodies were contaminated with Bacillus subtilis or Pseud...
متن کاملDiagnosis of postnatally acquired rubella by use of three enzyme-linked immunosorbent assays for specific immunoglobulins G and M and single radial hemolysis for specific immunoglobulin G.
Three commercial indirect enzyme-linked immunosorbent assays (ELISAs) (RUBELISA, Enzygnost-Rubella, and Rubazyme) and a commercial single radial hemolysis (SRH) test (Rubazone) were evaluated for the diagnosis of acute rubella by testing 41 acute- (less than 7 days postonset) and convalescent-phase (8 to 82 days postonset) serum pairs from cases of rubella previously confirmed by significant ch...
متن کاملThe prevalence of adverse obstetric outcomes follow of an abnormal maternal serum AFP and NTDs screen positive group
Introduction: Prenatal maternal serum AFP screening tests have some inherent false positive and false negative results. For NTDs Screening test (FTS) false positive rate (FPR) is about 1% and false negative rate (FNR) is 20%. A false positive result encourages by Anomaly scan and invasive diagnostic procedures (that poses lots of stress on women, too), while a false negative result lead to a N...
متن کاملIgM-class rheumatoid factor interference in the solid-phase radioimmunoassay of rubella-specific IgM antibodies.
The interference of IgM-class rheumatoid factor (RF) in the solid-phase radioimmunoassay (RIA) of rubella virus IgM antibodies was studied. Acute rubella infections did not significantly activate RF. False-positive rubella antibody results were obtained, however, when patients with raised RF levels were tested. If a low rubella IgG antibody titre was present, a high level of RF was required to ...
متن کامل